Search results for "MESH: Iron Overload"

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Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic ir…

2014

Hepatitis C virus (HCV)-induced iron overload has been shown to promote liver fibrosis, steatosis, and hepatocellular carcinoma. The zonal-restricted histological distribution of pathological iron deposits has hampered the attempt to perform large-scale in vivo molecular investigations on the comorbidity between iron and HCV. Diagnostic and prognostic markers are not yet available to assess iron overload-induced liver fibrogenesis and progression in HCV infections. Here, by means of Spike-in SILAC proteomic approach, we first unveiled a specific membrane protein expression signature of HCV cell cultures in the presence of iron overload. Computational analysis of proteomic dataset highlighte…

Liver CirrhosisProteomicshepatitis C virusMaleMESH: Isotope LabelingHSCmedicine.disease_causeBiochemistry0302 clinical medicineFibrosisMESH: Up-RegulationMembrane Proteinhepatic stellate cellliver fibrosishepatic iron overload0303 health sciencesbiologyMESH: ProteomicsMedicine (all)hepatocellular carcinomaBiomedicine; hepatitis c infection; liver fibrosis; hepatic iron overload; vitronectinHepatitis C[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]Hepatitis CUp-Regulation3. Good healthcell culture-derived HCVIsotope Labeling030220 oncology & carcinogenesisHepatocellular carcinomaBiomedicine; Hepatic iron overload; Hepatitis C infection; Liver fibrosis; Vitronectin; Biomarkers; Cell Line; Hepatitis C; Humans; Iron Overload; Isotope Labeling; Liver Cirrhosis; Male; Membrane Proteins; Proteomics; Up-Regulation; Vitronectin; Molecular Biology; Biochemistry; Medicine (all)HCV[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyBiomarker (medicine)VitronectinMESH: Membrane ProteinsMESH: Liver CirrhosisHumanIron OverloadLiver CirrhosiHepatitis C virusvitronectinhepatitis c infectionCell LineMESH: Iron Overload03 medical and health sciencesmedicineHumans[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyMolecular Biology030304 developmental biologyMESH: Hepatitis CMESH: HumansMESH: Biological MarkersMembrane ProteinsLiver fibrosiProteomicBiomarkermedicine.diseaseMESH: VitronectinMESH: Maledigestive system diseasesMESH: Cell LineBiomedicineBiomedicine / Abbreviations: HCCHCVccImmunologyCancer researchHepatic stellate cellbiology.proteinSteatosisBiomarkersPROTEOMICS
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Liver methylene fraction by dual- and triple-echo gradient-echo imaging at 3.0T: Correlation with proton MR spectroscopy and estimation of robustness…

2011

Purpose To assess the systematic errors in liver methylene fraction (LMF) resulting from fat–fat interference effects with dual- and triple-echo gradient-recalled-echo Dual/Triple GRE) sequences and to test the robustness of these sequences after iron overloading. Materials and Methods Forty type-2 diabetic patients underwent LMF measurement by 3.0T 1H magnetic resonance spectroscopy (corrected for T1 and T2 decays) as the reference standard and liver fat fraction (%Fat) measurement by four Dual/Triple GRE sequences with 20° and 60° flip angle (α), corrected for T1 recovery. The same four sequences were repeated in eight patients after ferumoxide injection. Corrections for systematic errors…

MaleMagnetic Resonance SpectroscopyMESH : Fatty LiverMESH: Echo-Planar Imaging[SDV]Life Sciences [q-bio]Carbon Compounds InorganicMESH : Statistics as TopicStatistics as TopicMESH : AgedContrast MediaMESH : Carbon Compounds InorganicMESH : Tissue Distribution030218 nuclear medicine & medical imagingCorrelationchemistry.chemical_compound0302 clinical medicineMESH : DextransNon-alcoholic Fatty Liver DiseaseMESH : FemaleTissue DistributionMESH: DextransMethyleneMagnetite NanoparticlesMESH: Fatty LiverMESH: AgedMESH: Middle Agedmedicine.diagnostic_testEcho-Planar ImagingDextransNuclear magnetic resonance spectroscopyMESH : AdultMiddle AgedMESH: Reproducibility of ResultsAdipose TissueLiverFemale030211 gastroenterology & hepatologyMESH : Sensitivity and SpecificityProtonsMESH: Adipose TissueAdultIron OverloadMESH : MaleMESH: Magnetite NanoparticlesMESH : Adipose TissueSensitivity and SpecificityMESH: Iron Overload03 medical and health sciencesFlip angleRobustness (computer science)MESH: Contrast MediaLinear regressionmedicineMESH : ProtonsHumansMESH : Middle AgedRadiology Nuclear Medicine and imagingMESH: Tissue DistributionMESH: Statistics as TopicAgedMESH : Contrast MediaMESH : Iron OverloadMESH: HumansMESH : Echo-Planar Imaging[ SDV ] Life Sciences [q-bio]MESH: Magnetic Resonance Spectroscopybusiness.industryMESH : Reproducibility of ResultsMESH : HumansMESH: Biological MarkersMESH: Carbon Compounds InorganicMESH : LiverMESH : Magnetite NanoparticlesReproducibility of ResultsMESH: AdultMagnetic resonance imagingMESH: MaleMESH: Sensitivity and SpecificityProton mr spectroscopyMESH : Biological MarkersFatty LiverchemistryMESH : Magnetic Resonance SpectroscopyMESH: ProtonsNuclear medicinebusinessMESH: FemaleBiomarkersMESH: LiverJournal of Magnetic Resonance Imaging
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